MKRN3 (Makorin3, ZNF127) is paternally expressed and putatively encodes a 505 amino acid
polypeptide-containing zinc-finger motif (Jong
MTC et al 1999; Glenn
CC et al, 1997; Glenn CC et al, 1993; Driscoll
DJ et al, 1992).
Mutations of MKRN3 are associated with precocious puberty when paternally inherited (Abreu AP et al, 2013; Simon D et al, 2016).
An antisense transcript MKRN3-AS1 (ZNF127AS, FNZ127, DN34) has been reported
but its imprinting status is not yet known (Jong
MTC et al, 1999): the mouse homologue Mkrn3os (Zfp127as) is reported to be paternally expressed.