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Description:
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SLC22A18AS (solute carrier family 22 (organic cation transporter), member 18 antisense; SLC22A1LS;
BWR1B; BWSCR1B; ORCTL2S) showed monoallelic expression in multiple tissues from 2 spontaneously
aborted fetuses. The parental origin of the expressed allele could be determined in one fetus. It
was maternally expressed (Bajaj
V et al, 2004).
Dao et al (1998)
stated that SLC22A18LS (under the name 2G3-8) was under study, but that it may
show allelic expression bias in some tissues.
Biallelic expression was observed of six informative reduction mastectomy samples, although
three of these showed possible allelic imbalance (Gallagher E et al, 2006).
Morcos L et al (2011) found no evidence
of allelic
expression bias in lymphoblast cell lines.
Baran Y et al (2015) found no evidence of
imprinting of SLC22A18AS (using RNA-seq) in multiple adult tissues (subcutaneous adipose, brain,
transverse colon,
liver and whole blood).
On balance there is insufficient evidence to include SLC22A18AS in the list of imprinted genes.
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