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Description:
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An alternative transcript of WT1 (Wilms tumour 1), AWT1, is reported to be paternally expressed in
kidney, together with the WT1 antisense transcript. Although monoallelic expression was clearly
demonstrated, paternal expression
was only demonstrated in one normal kidney sample, and was inferred from continued expression in two
Wilms tumours with loss of heterozygosity and retention of the paternal allele (Dallosso
AR et al, 2004).
WT1 was previously reported to be partially or completely imprinted and maternally expressed in 5 of
9 preterm placentas and in 2 fetal brains (Jinno
Y et al, 1994), and in 7 of 19 placental villus samples from gestational age 4 to 21 weeks (Nishiwaki
K et al, 1997) but was paternally expressed in fibroblasts and lymphocytes from two of seven
individuals
(Mitsuya
K et al, 1997).
In contrast equal expression of WT1 alleles has been reported for fetal kidney (Little
MH et al, 1992). Biallelic expression of WT1 was detected in 6/6 human embryonic cell lines (Kim
KP et al, 2007).
Baran Y et al (2015) found no evidence of
imprinting in multiple adult tissues.
De novo germ line deletions of WT1 preferentially (7/8) occur during male gametogenesis - this not
regarded as an imprinting effect (Huff
V et al, 1990).
See also WT1-AS.
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