Peg3 (Pw1) is a paternally expressed, zinc finger protein. Peg3 is expressed in early somites, branchial
arches and other mesodermal tissues, as well as in the hypothalamus (Kaneko-Ishino
T et al, 1995; Kuroiwa
Y et al, 1996).
Loss of Peg3 expression results in reduced maternal care, reduced maternal food intake during
pregnancy, reduced milk let-down, reduced placental size, impaired fetal growth, suckling and
postnatal growth, and delayed puberty (Curley
JP et al, 2004).
et al, (2005) have described a Peg3 antisense transcript in rat (APeg3). It imprinting status is
not yet known.
Bisulfite sequencing revealed that reactivation of maternal alleles of Peg3 in
specific tissues was accompanied by partial demethylation at their potential imprinting control
W et al, 2005).
Imprinted paternal expression of Peg3 was confirmed in placenta (Wang X et al, 2011 and Okae H et al, 2012 ).