RNU5D-1 (RNA, U5D small nuclear 1) was monoallelically and exclusively paternally expressed in (?) one human
induced pluripotent stem cell line and in one human embryonic stem cell line. It was not expressed in two
parthenogenetic human induced pluripotent stem cell lines (Stelzer Y et al, 2011).
Baran Y et al (2015) found no evidence of
imprinting of RNU5D-1 (using RNA-seq) in adult subcutaneous adipose, tibial artery, transformed fibroblasts, sun
exposed skin, whole blood and EBV-transformed lymphocytes.
Although the data appear internally consistent, the number of independent samples analysed is too small to ascribe
imprinting with confidence. There are no known neighbouring imprinted genes. The genomic region encompassing
RNU5D-1 is highly conserved across mammals.