Taxon:

Human

Gene:

RNU5D-1 (provisional)

Chromosome:

01

Location:

1p34.1

Description:

RNU5D-1 (RNA, U5D small nuclear 1) was monoallelically and exclusively paternally expressed in (?) one human induced pluripotent stem cell line and in one human embryonic stem cell line. It was not expressed in two parthenogenetic human induced pluripotent stem cell lines (Stelzer Y et al, 2011).
Baran Y et al (2015) found no evidence of imprinting of RNU5D-1 (using RNA-seq) in adult subcutaneous adipose, tibial artery, transformed fibroblasts, sun exposed skin, whole blood and EBV-transformed lymphocytes.
Although the data appear internally consistent, the number of independent samples analysed is too small to ascribe imprinting with confidence. There are no known neighbouring imprinted genes. The genomic region encompassing RNU5D-1 is highly conserved across mammals.

Category:

Imprinted genes

Record:

1393

Last Modified 8/3/2017

Links:

Gene  


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