Taxon:

Human

Gene:

ZDBF2

Chromosome:

02

Location:

2q33.3

Description:

RT-PCR studies using human lymphocytes and the SNP analysis in the human placenta revealed that the human ZDBF2 (zinc finger, DBF-type containing 2) is paternally expressed in lymphocytes but biallelically expressed in the placenta. The placenta-specific escape from imprinting is similar to that observed in the imprinted mouse Zdbf2 gene (Kobayashi, H. et al, 2009).
Morcos L et al (2011) showed strongly biased paternal expression of ZDBF2 in human lymphoblast cell lines from nine informative parent-offspring trios.
Baran Y et al (2015) found evidence of imprinting of ZDBF2 (using RNA-seq) in multiple adult tissues (subcutaneous adipose, visceral adipose, adrenal gland, aorta, tibial artery, brain, mammary tissue, oesophagus muscularis, transformed fibroblasts, atrial appendage, left ventricle, EBV-transformed lymphocytes, lung, skeletal muscle, tibial nerve, ovary, prostate, pituitary, stomach, thyroid). No evidence of imprinting was seen in pancreas and testis tissues.

Category:

Imprinted genes

Record:

1271

Last Modified 8/3/2017

Links:

Gene  Unigene  


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