Taxon:

Human

Gene:

miR-134, DLK1-GTL2

Chromosome:

14

Location:

14q32

Description:

The brain-specific microRNA miR-134 lies within the DLK1-GTL2 imprinted domain and is thought to regulate localised translation of Limk1 mRNA, which encodes a regulator for the size of dendritic spines in neurons, based on observations in the rat (Schratt GM et al, 2006). Limk1 translation is reversible by BDNF. See Royo H et al, 2008 for a review.

Category:

Imprinted genes

Record:

1251

Last Modified 5/19/2010

Links:

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