Taxon:

Human

Gene:

MIR483 (hsa-mir-483)

Chromosome:

11

Location:

11p15.5 (02)

Description:

MIR483 (hsa-mir-483) is located within intron 7 of IGF2 (Fu H et al, 2005). The mature form, miR-483-3p, is overexpressed in Wilms tumours, as well as in 30% of colon, breast and liver cancers (Veronese A et al, 2010). It has been proposed that miR-483-3p may protect cells from apoptosis (Veronese A et al, 2010).
The imprinting status of miR-483-3p is not yet known, but because it is transcribed off the same strand as IGF2 it is likely to be paternally expressed.

Category:

Imprinted genes

Record:

1250

Last Modified 6/27/2010

Links:

Gene  


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