Taxon:

Human

Gene:

KLF14

Chromosome:

07

Location:

7q32.3

Description:

KLF14 (Krüppel-like factor 14) is a maternally expressed intronless transcription factor located telomeric of COPG2 (Parker-Katiraee L et al, 2007).
KLF14 acts as a master trans regulator of adipose gene expression. The expression levels of these are highly correlated with concurrently measured metabolic traits (Small KS, 2011).

Baran Y et al (2015) reported that allelic expression of KLF14 in multiple adult tissues (subcutaneous adipose, visceral adipose, adrenal gland, skeletal muscle and tibial nerve) was consistent with imprinting of this gene (using RNA-seq). No evidence of imprinting of KLF14 was seen in testis and whole blood tissues.

Category:

Imprinted genes

Record:

1112

Last Modified 8/3/2017

Links:

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