Taxon:

Human

Gene:

ZNF331 (ZNF463) (provisional evidence)

Chromosome:

19

Location:

19q13.41 58.8 Mb

Description:

ZNF331 (ZNF463; zinc finger protein 331) was maternally expressed in lymphoblastoid cell lines from five children in a single CEPH family. Six unrelated individuals showed monoallelic expression of SNPs in the 3' end of ZNF331, but biallelic expression of SNP in the 5' UTR (Pant PV et al, 2006). In contrast the same group later reported a pattern of differential allelic expression that was suggestive of paternal expression (Pollard KS et al, 2008).
By using genome-wide allele-specific protein-DNA interaction studies (ChIP-SNP), Maynard ND et al (2009) found allele-specific binding of RNA polymerase II to ZNF331.
Three reference sequence transcripts of ZNF331 are known. The apparent discrepancies in the parent-of-origin may be attributable to isoform specific imprinting (additional data are needed). Biallelic expression was detected in the 5'UTR of the most 5' transcript (NM_018555).

Category:

Imprinted genes

Record:

1106

Last Modified 7/27/2009

Links:

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