Taxon:

Human

Gene:

INPP5F (INPP5F_V2)

Chromosome:

10

Location:

10q26.11

Description:

Isoform 2 of INPP5F (INPP5F_V2; inositol polyphosphate-5-phosphatase F, isoform 2) was exclusively expressed from the paternal allele in fetal brain, heart and tongue in one informative fetus, and monoallelically expressed in two additional fetuses (same tissues). Its promoter shows germline maternal methylation (Wood AJ et al, 2007). Mouse Inpp5f_v2 is also imprinted and paternally expressed.
INPP5F_V2 is a retrogene derived from the X chromosome gene TMEM114A. Isoform 2 probably does not encode a protein.
INPP5F_V2 is present in all eutherian mammals but is absent from the opossum genome.
Morcos L et al (2011) found no evidence of allelic expression bias in lymphoblast and fibroblast cell lines.

Category:

Imprinted genes

Record:

1081

Last Modified 10/18/2015

Links:

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