PSIMCT-1 (MCTS1 pseudogene; referred to as MCTS2 (malignant T cell amplified sequence 2) by Wood et
al.) was exclusively expressed from the
paternal allele in fetal brain, heart and tongue in one
informative fetus, and monoallelically expressed in two additional fetuses (same tissues) (Wood
AJ et al, 2007). Mouse Mcts2 is also imprinted and paternally
PSIMCT-1 is reported to be a pseudogene derived from the X chromosome gene MCTS1/Mcts1 (Nandi
S et al, 2006). Despite 15 nucleotide differences the 181 aa open reading frame is conserved
with 95% identity to MCTS1. Thus Wood et al. believe it to be a functional retrogene.
PSIMCT-1 retrotransposed into intron 4 of HM13/H13 of mouse and human. It is absent in the genome of
cow and dog.