Taxon:

Mouse

Gene:

Ppp1r9a (neurabin)

Chromosome:

06

Location:

6 A1 (5), 1.86 cM, 50 Mb (GRCm38)

Description:

Ppp1r9a (neurabin) was first discovered as an actin filament binding protein in rats, and has subsequently been shown to regulate synapse formation in vitro. Neurabin is part of a cluster of imprinted genes on the mouse chromosome 6, which include Peg10 and Sgce which also have imprinted homologues on human chromosome 7. Ono R, et al (2003) found Ppp1r9a to be preferentially maternally expressed in the placenta (day 10) and yolk sac (day 10 and 13), while biallelic expression was observed in the brain Nakabayshi et al (2004) have shown preferential maternal expression of Ppp1r9a in embryonic skeletal muscle and extraembryonic tissues, but biallelic expression in other embryonic tissues.
Monk D et al, (2008) confirmed extra-embryonic specific preferential maternal expression.
Okae H et al, (2012) confirmed imprinted maternal expression of this gene in placenta and trophoblast stem cells (TS).

Category:

Imprinted genes

Record:

421

Last Modified 7/10/2016

Links:

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