Ppp1r9a (neurabin) was first discovered as an actin filament binding protein in rats, and has
subsequently been shown to regulate synapse formation in vitro. Neurabin is part of a cluster
of imprinted genes on the mouse chromosome 6, which include Peg10
which also have imprinted homologues on human chromosome 7. Ono
R, et al (2003) found Ppp1r9a to be preferentially maternally expressed in the placenta
(day 10) and yolk sac (day 10 and 13), while biallelic expression was observed in the brain Nakabayshi
et al (2004) have shown preferential maternal expression of Ppp1r9a in embryonic skeletal
muscle and extraembryonic tissues, but biallelic expression in other embryonic tissues.
D et al, (2008) confirmed extra-embryonic specific preferential maternal expression.
Okae H et al, (2012) confirmed
imprinted maternal expression of this gene in placenta and trophoblast stem cells (TS).