Taxon:

Human

Gene:

PEG10

Chromosome:

07

Location:

7q21.3 (94.1 Mb Build 36.1)

Description:

PEG10 (paternally expressed gene 10) is paternally expressed and is located next to SGCE which also shows evidence of paternal expression. PEG10 is a Sushi-ichi retrotransposon-derived gene with two predicted open reading frames similar to viral Gag and Pol proteins (Ono R, et al. 2001) and contains one intron. PEG10 is highly conserved amongst mammals, and mouse Peg10 and Sgce are also paternally expressed (Ono R, et al. 2003).
A maternally methylated germline DMR (reported in mouse) overlaps exon1 of PEG10 and SGCE (chr7:94122795-94124463 NCBI build 36.1) (Ono R, et al. 2003).
Baran Y et al (2015) found evidence of imprinting of PEG10 (using RNA-seq) in multiple adult tissues (adrenal gland, tibial artery, brain, mammary tissue, transformed fibroblasts, cortex of kidney, lung, tibial nerve, pituitary and testis).

Category:

Imprinted genes

Record:

415

Last Modified 8/3/2017

Links:

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