Morcos L et al, (2011) showed allelic expression
bias in fibroblast cell lines. Exclusive paternal expression was then shown in eight informative
A complex transcription unit including MEG8 (orthologous to mouse Rian, and sheep Meg8) is host to
three types of snoRNAs (SNORD112 [14q(0)], SNORD113 [14q(I)] and SNORD114 [14q(II)]). In mouse the
orthologous snoRNAs, and Rian are
maternally expressed, as is Meg8 in sheep (Cavaille J et al, 2002).
Baran Y et al (2015) found evidence of imprinting
of MEG8 (using RNA-seq) in adult adrenal gland, brain, ovary and pituitary tissues. Allelic expression of MEG8 in other
tissues was also consistent with imprinting (subcutaneous adipose, transformed fibroblasts, atrial appendage,
pancreas, testis, uterus and vagina).