Taxon:

Human

Gene:

MEG8 (SNORD112, SNORD113, SNORD114)

Chromosome:

14

Location:

14q32.31

Description:

Morcos L et al, (2011) showed allelic expression bias in fibroblast cell lines. Exclusive paternal expression was then shown in eight informative parent-offspring trios.
A complex transcription unit including MEG8 (orthologous to mouse Rian, and sheep Meg8) is host to three types of snoRNAs (SNORD112 [14q(0)], SNORD113 [14q(I)] and SNORD114 [14q(II)]). In mouse the orthologous snoRNAs, and Rian are maternally expressed, as is Meg8 in sheep (Cavaille J et al, 2002).
Baran Y et al (2015) found evidence of imprinting of MEG8 (using RNA-seq) in adult adrenal gland, brain, ovary and pituitary tissues. Allelic expression of MEG8 in other tissues was also consistent with imprinting (subcutaneous adipose, transformed fibroblasts, atrial appendage, pancreas, testis, uterus and vagina).

Category:

Imprinted genes

Record:

390

Last Modified 8/3/2017

Links:

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