Taxon:

Human

Gene:

WT1-AS (AWT1) (provisional)

Chromosome:

11

Location:

11p13

Description:

Monoallelic expression of WT1 antisense transcripts along with differential methylation of the antisense regulatory region suggests that WT1-AS may be imprinted. Paternal expression was documented in one case (Malik K et al, 2000; Dallosso AR et al, 2004).
Monoallelic expression of WT1-AS appeared to be controlled by a DMR in intron 1 referred to as ARR (at +2043 - 2893 bp relative to WT1 exon1; chr11:32,410,770-32,411,620) (Dallosso AR et al, 2004).
Baran Y et al (2015) found no evidence of imprinting in multiple adult tissues.

Category:

Imprinted genes

Record:

269

Last Modified 11/25/2018

Links:

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