IGF2R (M6PR) is maternally expressed in sheep (Killian
JK et al, 2001; Thurston
A et al 2008). The second intron differentially methylated region (DMR2) in IGF2R in sheep
shows differential methylation (suggestive of imprinting). Hypomethylation of DMR2 (in mice,
hypomethylation is associated with loss of IGF2R expression) was associated with "large offspring
LE et al, 2001).