ZNF215 is a zinc finger gene 3.9 Mb centromeric of OSBPL5 the most centromeric of the imprinted
genes in the KCNQ1 imprinting cluster on 11p15.5. It has five alternatively spliced isoforms, two of
which were preferentially expressed from the maternal allele in tissues from two fetuses (SSCP
analysis of nested RT-PCR products) (Alders
M et al, 2000).
Extract from paper: "The maternal allele of ZNF215V1 is preferentially expressed in liver, lung,
kidney, and testis but also that, in the brain and heart, these alleles are nearly equally
expressed. Interestingly, ZNF215V3 also is partially imprinted in lung, liver, and kidney but is
completely imprinted in heart. In brain tissue, however, complete imprinting is seen in fetus 2,
whereas, in fetus 1, both alleles are expressed indicating either that, at least in this tissue,
individual variation exists or that imprinting may vary in different stages of development"
However, Morcos L et al, (2011) found no evidence of
allelic expression bias in lymphoblast and fibroblast cell lines.