Taxon:

Human

Gene:

SLC22A18 (BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5)-[status questioned]

Chromosome:

11

Location:

11p15.5 (10a)

Description:

SLC22A18 (solute carrier family 22 (organic cation transporter), member 18, BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5) is relatively repressed on the paternal allele in some tissues (Dao D et al, 1998; Cooper PR et al, 1998; Schwienbacher C et al, 1998; Lee MP et al, 1998).
Analysis of peripheral blood samples revealed biallelic expression, but with a significant bias towards the maternal allele (Sakatani T et al 2001). Monoallelic expression was detected in only 1 of 4 benign reduction mastectomy tissues and in 2 of 11 malignant breast tissues (Gallagher E et al, 2006).
Biallelic expression was detected in 7/7 human embryonic stem cell lines (Kim KP et al, 2007).
Morcos L et al, (2011) found no evidence of allelic expression bias in lymphoblast and fibroblast cell lines for the gene SLC22A18.

Category:

Imprinted genes

Record:

33

Last Modified 7/15/2012

Links:

Gene  


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