Taxon:

Human

Gene:

IGF2

Chromosome:

11

Location:

11p15.5 (02)

Description:

IGF2 (Insulin-like growth factor 2, a fetal growth factor) is paternally expressed in nearly all human tissues. Expression is not imprinted in the choroid plexus, leptomeninges, brain, bone marrow, adult human liver and chondrocytes. Its imprinting is under the control of enhancers upstream of the H19 locus (Rainier S, 1993; Ogawa O, 1993; Ohlsson R, 1993). Analysis of imprinting of IGF2 in peripheral blood suggest imprinting maybe polymorphic, with biallelic expression being observed in ~10% of individuals (4 of 38 in japanese sample)(Sakatani T et al 2001).
IGF2 has two secondary (post-fertilisation) DMRs. DMR0 is in intron 2, and shows maternal methylation (Sullivan M et al, 1999). DMR2 overlaps intron 8 and exon 9 and shows maternal methylation (demonstrated at 2 HpaII sites) in human blood (Reik W et al, 1994; Reik W et al, 1995).

Category:

Imprinted genes

Record:

26

Last Modified 7/7/2017

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