Taxon:

Mouse

Gene:

Mest (Peg1)

Chromosome:

06

Location:

6 A3.3, 7.5 cM

Description:

Mest (Peg1, Paternally expressed gene 1, mesoderm-specific transcript) is paternally expressed (Kaneko- Ishino T et al, 1995).
Loss of Peg1 imprinting occurred in a subset of F1 hybrids between M. musculus and M. spretus (Shi W et al, 2004).
A maternally methylated germline DMR is located in the promoter of MEST (reported at chr6:30686710-30687273, adjacent to CpG island at chr6:30687908-30688499 NCBI build 37; Lucifero D et al, 2002).
Peg1/Mest expression (monoallelic) in upregulated in adipose tissue of obese mice (Kamei Y et al, 2006).
A longer (>10 kb) transcript of Mest, called MestXL, extends into the downstream antisense gene Copg2 . MestXL expression was tissue-specific, i.e., it was expressed in developing brain, but not in heart and liver (MacIsaac J L et al, 2012). MestXL expression controls the imprinting of Copg2 in tissues in which MestXL is expressed (see Copg2 entry). MestXL was previously identified as Mit1/Lb9 (Lee YJ et al, 2000)
Imprinted paternal expression of Mest was confirmed in placenta (Wang X et al, 2011 and Okae H et al, 2012 ) and in trophoblast stem cells (Okae H et al, 2012).

Category:

Imprinted genes

Record:

132

Last Modified 7/10/2016

Links:

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