Gnas (Gs-alpha), Gnasxl, Nesp, Nespas, F7, miR-296, miR-298




104 cM, Band E1-H3


Gnas (Gs-alpha), Gnasxl, Nesp, Exon 1A transcript and Nespas (antisense) are transcripts from the Gnas gene locus.
Nesp shows maternal expression whereas
Gnasxl, and the Exon 1A transcript are paternally expressed (Peters J et al, 1999; Li T et al, 2000; Liu J et al, 2000). Multiple transcripts and protein isoforms are derived from the XL (XXL) promoter (Abramowitz J et al, 2004).
Gnas (Gs-alpha) showed biallelic expression in most tissues (Peters J et al, 1999), but preferential expression of the maternal allele in proximal tubule cells and in brown and white adipose tissue (Yu S et al, 1998; Weinstein LS et al, 2000). Gnas imprinting is controlled by the DMR at exon 1A (Williamson CM et al, 2004).
Nespas (neuroendocrine secretory protein antisense) is a paternally expressed antisense transcript from the Gnas gene locus (Wroe SF et al, 2000). In addition to the unspliced form there are five alternatively spliced forms of Nespas in mouse (Williamson CM et al, 2002).
Nespas hosts two microRNAs. Robson, JE et al, (2012), provided evidence for exclusive paternal expression of MicroRNA-296-5p and MicroRNA-298 in mouse embryos.
(Also see Yu S et al, 1998; Williamson CM et al, 1996; Li T et al, 2004).
A maternally expressed transcript, F7, between Gnasxl and Exon1a, has been reported (Holmes R et al, 2003).
For other studies on the location of imprint control regions see Williamson CM et al, 2006, Liu J et al, 2000 and Coombes C et al, 2003.


Imprinted genes



Last Modified 2/4/2013



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