Ins1 may be paternally expressed, but there are conflicting data. It was reported to be imprinted in
yolk sac at day 16, but not in the pancreas (Giddings
SJ et al, 1994). Deltour et al found no evidence of imprinting at in embryo bodies at days 12.5,
13.5, and 14.5 (Deltour
L et al, 1995). Furthermore they failed to find evidence of expression in the yolk sac in
several common laboratory mouse strains, they found low asynchrony of replication and no evidence of
imprinting of a neo gene inserted at the Ins1 locus (Deltour
L et al, 2004). It has no human orthologue.