Taxon:

Mouse

Gene:

Axin1, Fused, Fu

Chromosome:

17

Location:

11.8 cM

Description:

The penetrance of the Fu allele of the Fused (Axin1) gene was strongly dependent on its parental origin. For example, when maternally inherited approximately 33% of heterozygotes had a fused skeletal phenotype compared to 81% when paternally inherited (Reed SC, 1937). The Fu mutation of Axin is attributable to the insertion of an intracisternal A particle (IAP) transposon between exons 6 and 7 of Axin1. IAP elements are known to be more methylated during spermatogenesis than oogenesis (Vasicek TJ et al, 1997).

Category:

Parental effect

Record:

105

Last Modified 2/16/2008

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