Taxon:

Mouse

Gene:

Rb1

Chromosome:

14

Location:

41.0 cM, Band D3

Description:

There is no direct evidence of imprinting but melanotroph tumours of the pituitary have an earlier onset when mutant Rb1 is paternally inherited (Harrison DJ et al, 1995; Nikitin AY et al, 1997).

An imprinted CpG island has been identified at the human RB1 locus, controlling expression of an alternative imprinted RB1 transcript, that is thought to have arisen from a degraded KIAA0649 pseudogene (Kanber D et al, 2009). There is no evidence to suggest imprinting of Rb1 in mice (Kanber D et al, 2009).

Category:

Parental effect

Record:

102

Last Modified 6/29/2010

Links:

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