Taxon:

Mouse

Gene:

Rasgrf1 (Grf1, Cdc25Mm, p190)

Chromosome:

09

Location:

50.0 cM, E3.1

Description:

Rasgrf1 (RAS protein-specific guanine nucleotide-releasing factor 1) is paternally expressed, but the maternal allele is expressed at low levels (<10% of paternal levels) in brain (Plass C et al, 1996). Paternal expression is dependent on paternal methylation of a 41 bp direct tandem repeat (40 copies) 30 kb upstream of Rasgrf1 (Pearsall RS et al, 1999; Yoon BJ et al, 2002; de la Puente A et al 2002).
Yoon et al identified a repeated sequence 3' of the differentially methylated domain (DMD) that regulates imprinted expression (Yoon B et al, 2005).

Category:

Imprinted genes

Record:

95

Last Modified 1/7/2016

Links:

Gene  


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