Taxon:

Mouse

Gene:

Phlda2 (Tssc3, Ipl)

Chromosome:

07

Location:

69.5 cM (4), Distal

Description:

Phlda2 (pleckstrin homology-like domain, family A, member 2) shows maternal expression with relative repression of the paternal allele. It is expressed in placenta and most fetal tissues (Qian N, et al. 1997). Tssc3-null mice and heterozygous mutants with maternal deletions show a placental overgrowth phenotype that does not confer a fetal growth advantage (Frank D et al, 2002). Syntenic with human 11p15.5.
Okae H et al, (2012) confrimed imprinted maternal expression of Phlda2 in trophoblast stem cell.

Category:

Imprinted genes

Record:

94

Last Modified 2/4/2013

Links:

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