Taxon:

Mouse

Gene:

Cd81 (Tapa1)

Chromosome:

07

Location:

69.3 cM (3), Distal

Description:

Relative repression of the paternal allele of Cd81 (Tapa1) in extraembryonic tissues, but not the embryos, during early development (days 9.5, 10.5, 17.5) has been reported (Umlauf D et al, 2004; Lewis A et al, 2004; Dao D et al, 1998; Caspary T et al, 1998;Kulinski TM et al, 2015).
But knockout experiments provide no evidence to support genomic imprinting (Maecker HT et al, 1998), and using somatic-cell hybrids no evidence of imprinting was found in human (Gabriel JM et al, 1998).
Proudhon and Bourc’his suggest that detection of preferential maternal expression in the placenta may be attributable to expression from maternal tissues. They propose that the imprinting status of this gene should be interpreted with caution (Proudhon and Bourc’his, 2010).

Category:

Imprinted genes

Record:

90

Last Modified 11/2/2015

Links:

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