Taxon:

Human

Gene:

MS4A2, FCERI, FCERIB (Fc epsilon RI-beta),

Chromosome:

11

Location:

11q13

Description:

MS4A2 (Membrane-spanning 4-domains, subfamily A, member 2). In allergic asthmatics the Leu181 allele was always maternally inherited (10/10 families) (Shirakawa T et al. 1994), while significant differences in linkage between maternal and paternal alleles has been observed (Daniels SE et al. 1996). In Japanese atopic siblings significantly increased sharing of maternal alleles was found (Mao XQ et al. 1997). In a panel of 60 families, significant sharing of maternal alleles was seen for atopic dermatitis and allele 2 of RsaI intron 2 and allele 1 of RsaI exon 7 (P = 0.0036) FCERIB gene polymorphisms (Cox HE et al. 1998). The most recent study examined association of allergen-induced skin-prick tests using specific IgE titres as a covariate. This showed mixed results with several SNPs showing significant (P < 0.01) maternal association with IgE titres (but not skin-prick/IgE-titre combination) in a panel of atopic asthma patients but not in a general population sample. A region of high CpG dinucleotide content also showed significant maternal association (P = 0.00001) to IgE titres in the atopic asthma panel. No mechanism has been identified to explain this maternal parent-of-origin effect (Traherne JA et al. 2003).

Category:

Parental effect

Record:

36

Last Modified 4/30/2010

Links:

LocusLink   OMIM    Unigene


*To look at further records use the Back button on your browser to return to the Summary Table

New Search

Home