Taxon:

Human

Gene:

IRAIN (IGF1R-AS) (provisional data)

Chromosome:

15

Location:

15q26.3

Description:

IRAIN (IGF1R antisense imprinted non-protein coding RNA, IGF1R-AS), a 5.3 kb antisense transcript originating in intron 1 of IGF1R, showed monoallelic paternal expression in five informative peripheral blood samples (Sun J et al, 2014; Kang L et al, 2015).
Monoallelic expression was detected in 18 breast cancers, in three additional blood samples, in KG-1 and KG-1a haematopoietic cell lines, and in MCF-7 breast cancer cells (Kang L et al, 2015).
At its promoter region, the CpG island showed methylated and unmethylated alleles in one normal haematopoietic stems cell sample, in KG-1 cells, in three acute myeloid leukaemia samples, and in two breast cancer samples, but dense methylation of all alleles for K562 cells and total unmethylation in MCF-7 and MDA-MB-231 breast cancer cell lines, in four breast cancer samples and in three blood samples (Sun J et al, 2014; Kang L et al, 2015).
The allele usage is interesting in that in 23 of 26 samples the expressed allele was the "A" allele (Sun J et al, 2014; Kang L et al, 2015).
Another unusual feature is that in two breast cancers the expressed allele was the "G" allele while in the blood from the same patients that "A" allele was expressed (Kang L et al, 2015). This allele switching together with the non-statistically significant number of cases (5) in which paternal expression was documented, suggest that the imprinting status of IRAIN should be regarded as provisional.

Category:

Imprinted genes

Record:

1399

Last Modified 1/8/2016

Links:

Gene  


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