Taxon:

Human

Gene:

RHOBTB3 (provisional)

Chromosome:

05

Location:

5q15

Description:

RHOBTB3 (Rho-related BTB domain containing 3) was differentially methylated in placentas and showed maternal methylation (Yuen RK et al, 2011). Monoallelic expression was detected in 3 of 4 informative placentas and in two of two informative families, expression was shown to be from the expected parent (presumably paternal but not stated).
Metsula T et al (2014) showed strong evidence of preferential paternal expression in the placentas in three informative families.
Given that the literature reports only 5 placentas that are informative for parent of origin expression, it would be useful to see additional independent data.

Category:

Imprinted genes

Record:

1379

Last Modified 3/4/2015

Links:

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