Taxon:

Cow

Gene:

MAGI2

Chromosome:

04

Location:

43 Mb (Build 5.2)

Description:

MAGI2 showed monoalleic expression in embryonic and extra-embryonic tissues of 18 d (cotyledon and brain) and 60 d (allantoid, amnios, muscle, brain, heart and intestine). The expressed allele was maternal, which is consistent with exclusive maternal expression in mice but different from the paternal expression of the human MAGI2 gene, as reported in the same study (Barbaux S et al, 2012).
The combination of polymorphic imprinting and opposite parents of origin in human vs mouse and cow, raises significant doubts about the validity of the authors' claims of imprinting.

Category:

Other

Record:

1357

Last Modified 1/29/2013

Links:

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