Taxon:

Mouse

Gene:

Magi2

Chromosome:

05

Location:

5 A3; 5

Description:

Magi2 showed monoalleic expression in F1 heterozygous placentas, in total placental cDNA, and in labyrinth and spongiotrophoblast extracts. The expressed allele was maternal, which is consistent with exclusive maternal expression in bovine samples, but different from the paternal expression of the human MAGI2 gene, as reported in the same study ( Barbaux S et al, 2012).
The combination of polymorphic imprinting and opposite parents of origin in human vs mouse and cow, raises significant doubts about the validity of the authors claims of imprinting.

Category:

Other

Record:

1356

Last Modified 12/29/2012

Links:

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