Taxon:

Human

Gene:

ZNF597

Chromosome:

16

Location:

16p13.3, 3.4 Mb

Description:

ZNF597 (zinc finger protein 597; previously called FLJ33071) showed predominant maternal expression in lymphoblast cell lines from 10 members of two CEPH pedigrees (Pant PV et al, 2006).
The ZNF597 promoter was identified as paternally methylated from analysis of androgenetic complete hydatidiform moles and maternally-derived mature cystic ovarian teratoma (Choufani S et al, 2011). This was confirmed by analysis of cases with genome-wide UPD. Methylation was restricted to the paternally derived allele in placenta, leukocyte and kidney. Maternal expression was observed in brain (n=1) and placenta (n = 3), and monoallelic expression was observed in leukocytes (n = 2) (Nakabayashi K et al, 2011).
ZNF597 was monoallelically expressed in 7 placentas and the expressed allele could be defined as maternal in 3 cases (Barbaux S et al, 2012).

Category:

Imprinted genes

Record:

1351

Last Modified 2/13/2017

Links:

Gene  


*To look at further records use the Back button on your browser to return to the Summary Table

New Search

Home