Taxon:

Human

Gene:

ZFAT

Chromosome:

08

Location:

8q24.22

Description:

ZFAT (zinc finger and AT hook domain containing) showed monoallelic expression in at least 9 placentas investigated, and in two cases the expressed allele could be determined and was paternal. However, biallelic expression was observed in human lymphocytes, endometrial tissue and thyroid tumours. None of the three CpG rich regions near ZFAT showed differential methylation. Biallelic expression was found in mouse E14.5 placentas and in bovine placentas (Barbaux S et al, 2012). Metsula T et al (2014) confirmed monoallelic expression but reported opposite parents-of-origin in two families. In contrast they reported that their results for ZFAT-AS1 were consistent with imprinted paternal expression but only three informative families were available.

Category:

Other

Record:

1348

Last Modified 3/3/2015

Links:

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