Cdh15 (cadherin-15) showed preferential paternal expression (from exons 13 and 14) in the adult
preoptic area (anterior hypothalamus) (Gregg
C et al, 2010).
A DMR that spans exons 10-12 of Cdh15 showed maternal-specific methylation in oocytes, 9.5 dpc
embryo, quadriceps, tail and hypothalamus, but the DMR was not maintained in adult cerebral cortex,
cerebellum and ES cells (Proudhon C et al,
2012). Cdh15 was showed exclusive paternal expression in the hypothalamus, and biallelic
expression in quadriceps and cerebellum. In the hypothalamus expression from exon 12-13 was 10-fold
higher than from exon 1, suggesting a specific imprinted transcript that arises between exons 9 and
10 (Proudhon C et al, 2012).