Taxon:

Human

Gene:

FAM50B and FAM50B-AS

Chromosome:

06

Location:

6p25.2

Description:

FAM50B showed monoallelic expression from the paternal allele in all fetal tissues (brain, liver, placenta, kidney, heart, testis and adrenal gland) except the ovary. Further, an antisense transcript, FAM50B-AS, was monoallelically expressed from the paternal allele in conceptus brain (n=1), adult liver (n=1) and adult testis (n=1). (Zhang A et al, 2011). Maintenance of monoallelic expression was shown in adulthood in testis and liver (n=1). Maternal methylation in the placental, kidney, leukocytes and paternal expression in 6 placentas was confirmed by Nakabayashi K et al (2011).
FAM50B showed preferential expression from the paternal allele in placenta (Yuen RKC et al, 2011). Pyrosequencing of FAM50B in 12 normal placenta and 10 maternal blood samples showed consistent methylation of the maternal allele.

Category:

Imprinted genes

Record:

1319

Last Modified 1/31/2017

Links:

Gene  


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