Taxon:

Mouse

Gene:

Cntn3 (Status questioned)

Chromosome:

06

Location:

6 D3; 6 43.5 cM

Description:

Cntn3 is one of the ten genes reported by Brideau et al to be imprinted and maternally expressed in the mouse placenta. No evidence of imprinting was detected in E17.5 brain from reciprocal crosses. They also stated that Cntn3 is unlikely to be controlled by an ICR (Brideau CM et al, 2010).
However, Okae H et al (2012) reported negligible expression of Cntn3 by qPCR and whole transcriptome sequencing in E13.5 placentas. They suggest that this gene is not imprinted. This is concordant with a caution from Proudhon and Bourc'his (2010) that maternal contamination of placental tissues may cause apparent imprinted maternal expression.

Category:

Other

Record:

1292

Last Modified 11/2/2015

Links:

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