Taxon:

Mouse

Gene:

Fbxo40 (Status questioned)

Chromosome:

16

Location:

16 B3; 16

Description:

Fbxo40 (F-box protein 40) is one of the ten genes reported by Brideau et al to be imprinted and maternally expressed in the mouse placenta. No evidence of imprinting was detected in E17.5 brain from reciprocal crosses. However, for Fbxo40 the evidence was more apparent for one direction of the cross than the other (Brideau CM et al, 2010).
However, Okae H et al (2012) reported negligible expression of Fbxo40 by qPCR and whole transcriptome sequencing in E13.5 placentas. They suggest that this gene is not imprinted. This is concordant with the caution from Proudhon and Bourc'his (2010) that maternal contamination of placental tissues may cause apparent imprinted maternal expression.

Category:

Other

Record:

1277

Last Modified 11/2/2015

Links:

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