Taxon:

Mouse

Gene:

Zdbf2, Zdbf2linc

Chromosome:

01

Location:

1 C2

Description:

Zdbf2 (zinc finger, DBF-type containing 2) was paternally expressed in various embryonic and adult tissues. In the placenta and adult testis, biallelic expression was observed (Kobayashi H et al, 2009). Three paternally methylated DMRs are located upstream of Zdbf2. Although present in the germline, these DMRs appear to be re-established after implantation and therefore might be regarded as secondary DMRs (Kobayashi H et al, 2012).
Zdbf2linc (a long intergenic non-coding splice variant of Zdbf2) which is transcribed from the Gpr1 DMR, is expressed from E3.5 to E7.5, from the paternal allele (Kobayashi H et al, 2012). It may have a role in establishing the Zdbf2 DMRs after implantation.
Okae H et al (2012) (supplementary table S1) and Wang X et al (2011) reported imprinted paternal expression of Zdbf2 in mouse placentas.

Category:

Imprinted genes

Record:

1269

Last Modified 2/19/2016

Links:

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