pyrosequencing analysis, NLRP2 (NLR family, pyrin domain containing 2) showed subtle preferential
expression of the maternal
allele in 5 of 8 placentas, and allelic imbalance in the heart and kidney from two fetuses (Bjornsson
HT et al, 2008). Data from two somatic
issues are insufficient to demonstrate imprinting.
Note: Expression studies in the placenta
carry the risk that preferential
maternal expression reflects maternal decidual contamination of the specimen.
Baran Y et al (2015) found that although
NLRP2 was monoallelically expression, expression showed a mixed parent of origin, indicating that it
is not imprinted.