Taxon:

Human

Gene:

"early-onset obesity", DLK1

Chromosome:

14

Location:

14q32.2

Description:

Polymorphisms within DLK1 were examined for association with early-onset obesity in 359 children (Wermter AK et al, 2008). One SNP (rs1802710 T/C) within exon 5 showed increased paternal transmission of the C allele. However, relative risk for C homozygotes was not increased and leading to a hypothesis of “polar overdominance” (see callipyge sheep entry). Similar results were shown from repetition with a second cohort of 666 affected families (Wermter AK et al, 2008). No causal mutation could be identified. The rs1802710 SNP was located close to a pig polymorphism that is assoicated with decreased fat deposition (Kim K et al, 2004). For both pig and human the SNP creates a new CpG site.

Category:

Parental effect

Record:

1245

Last Modified 6/27/2010

Links:


*To look at further records use the Back button on your browser to return to the Summary Table

New Search

Home