Taxon:

Pig

Gene:

DLX5

Chromosome:

Unknown

Location:

Description:

Imprinting status of DLX5 (distal-less homeobox 5) was examined in Meishan and White Composite breeds. There was no evidence for imprinting in brain, fibroblast, liver and placenta (Bischoff SR et al, 2009).
Previously DLX5 gene was reported to be maternally expressed in skeletal muscle, fat, lung, spleen, stomach and small intestine, but not imprinted in heart, liver, kidney, uterus, ovary, testicle or pituitary, in eight heterozygous pigs from Large White x Meishan F1 hybrids crosses (Cheng HC et al, 2008). The complete repression of the paternal allele in imprinted tissues contrasts strikingly with uniform biallelic expression in other tissues. It is remarkable the skeletal muscle is imprinted whereas cardiac muscle is not. This report is difficult to reconcile with Bischoff’s report and evidence that human DLX5 is not imprinted (Schule B et al, 2007; Monk D et al, 2008)

Category:

Other

Record:

1197

Last Modified 11/11/2012

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