Taxon:

Mouse

Gene:

Sfmbt2 (Mir466b, Mir467a, Mir669a, Mir297)

Chromosome:

02

Location:

06.6 cM, Band A1, 10.3 Mb (Build 37)

Description:

Sfmbt2 (Scm-like with four mbt domains 2) is expressed preferentially from the paternal allele in early embryos, and in later stage extraembryonic tissues. A CpG island spanning the transcriptional start site is differentially methylated on the maternal allele in e14.5 placenta (Kuzmin A et al, 2008).
Okae H et al (2012) confirmed imprinted paternal expression of Sfmbt2 in placenta and trophoblast stem cells.
Wang Q et al (2011) showed exclusive expression from the paternal allele in placenta and yolk sac, whereas brain showed bialleic expression. Intron 10 of Sfmbt2 hosts a large block of miRNAs (containing Mir466b, Mir467a, Mir669a, Mir297) which is absent in human, bovine and Peromyscus (Wang Q et al, 2011; Lehnert S et al, 2011). Since Sfmbt2 is imprinted in mouse and rat only they proposed that this miRNA block is driving imprinting of this gene.

Category:

Imprinted genes

Record:

1162

Last Modified 10/18/2015

Links:

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