Ddc (Dopa decarboxylase) exon 1a transcript is paternally expressed in trabecular cardiomyocytes of
the embryonic and neonatal heart. Ddc displays tight conserved linkage with the maternally expressed
and methylated Grb10 gene, suggesting that these reciprocally imprinted genes may be co-ordinately
TR et al, 2007).
Shiura H et al (2009) reported slightly
biased expression from paternal alleles of Ddc-exon1 in yolk sac and liver, but not in embryos. The
exon1a transcript had paternally biased expression in embryos. In addition, they confirmed that
Ddc-exon1a exhibited heart-specific paternal expression in neonates, whereas it was biallelically
expressed in neonatal brain.