Taxon:

Mouse

Gene:

Ddc

Chromosome:

11

Location:

07.0 cM, Band A1

Description:

Ddc (Dopa decarboxylase) exon 1a transcript is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Ddc displays tight conserved linkage with the maternally expressed and methylated Grb10 gene, suggesting that these reciprocally imprinted genes may be co-ordinately regulated (Menheniott TR et al, 2007).
Shiura H et al (2009) reported slightly biased expression from paternal alleles of Ddc-exon1 in yolk sac and liver, but not in embryos. The exon1a transcript had paternally biased expression in embryos. In addition, they confirmed that Ddc-exon1a exhibited heart-specific paternal expression in neonates, whereas it was biallelically expressed in neonatal brain.

Category:

Imprinted genes

Record:

1158

Last Modified 1/25/2016

Links:

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