Taxon:

Pig

Gene:

MEST

Chromosome:

18

Location:

16.5 Mb

Description:

MEST (mesoderm specific transcript) is reported to be imprinted in pig placentas at 75 and 90 days of gestation as well as in 75 day fetal heart, muscle, kidney, lung and liver (Xu C et al, 2007). However, the paper only describes monoallelic expression, without parental origin, in an unspecified number of animals (at least 5). Of concern, all animals apparently expressed the 156 bp A allele.
Paternal expression was supported by low expression in parthenogenetic embryos (Bischoff SR et al, 2009).
Tissue-specific imprinting of MEST has been reported. MEST was paternally expressed in skeletal muscle, fat, pituitary, heart, kidney, lung, stomach, and uterus, whereas it was reported to be preferentially maternally expressed in spleen and liver (Zhang FW et al, 2012).

Category:

Imprinted genes

Record:

1144

Last Modified 1/6/2016

Links:

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