Taxon:

Mouse

Gene:

Dlk1-Gtl2 DMRs, Ig-DMR

Chromosome:

12

Location:

54.0 cM (3)

Description:

The Dlk1-Gtl2 locus carries three differentially methylated regions (DMRs), which are methylated only on the paternal allele, the Dlk1 DMR in the 3' region of the Dlk1 gene, the intergenic (IG) DMR located 12 kb upstream of Gtl2 and the Gtl2 DMR across the promoter and 5' portion of the Gtl2 gene.
Of these, the intergenic (IG) DMR, located 12 kb upstream of Gtl2 is the germline imprint control region (ICR) for this cluster (Lin SP et al, 2003).
Kota SK et al (2014) found that the unmethylated maternal allele activates imprinted expression using a mechanism linked to bidirectional expression of noncoding RNAs (ncRNAs) from the ICR.
The Gtl2 DMR begins approximately 1.5 kb upstream of Gtl2, continuing for at least 7.1 kb of Gtl2 (Takada S et al, 2000) but acquires its methylation postfertilization (Schmidt JV et al, 2000; Carr MS et al, 2007).

Category:

DMR or ICR

Record:

1138

Last Modified 3/12/2015

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