Taxon:

Mouse

Gene:

ICR - Airn (Air, Igf2r, Slc22a2, Slc22a3)

Chromosome:

17

Location:

07.36 cM, proximal

Description:

The ICR for this cluster is in intron 2 of Igf2r, it is methylated on the maternal allele and contains the Airn promoter (Sleutels F et al, 2002). The mechanism through which the Airn transcript or the act of transcribing Airn imprints adjacent genes (Igf2r, Slc22a2, Slc22a3) is unclear (Seidl C et al, 2006).
Okae H et al (2012) confirmed imprinted maternal expression of this gene in the placenta.

Category:

DMR or ICR

Record:

1117

Last Modified 1/8/2016

Links:

Gene  


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