Data regarding the imprinting of ZNF331 (ZNF463; zinc finger protein 331) are contradictory.
It was reported to be maternally expressed in lymphoblastoid cell lines from
five children in a single CEPH family. Six unrelated individuals showed monoallelic expression of
SNPs in the 3' end of ZNF331, but biallelic expression of SNP in the 5' UTR (Pant
PV et al, 2006).
In contrast the same group later reported a pattern of differential allelic
expression that was suggestive of paternal expression (Pollard
KS et al, 2008).
Diplas AI et al (2009) reported that
ZNF331 was expressed but not imprinted in the placenta.
Daelemans C et al (2010) reported
imprinting of ZNF331 with maternal expression in human placenta. Using two SNPs on the Illumina
system, rs8100247 (exon 1, 5'UTR) and rs12982082 (exon 2, 5'UTR), ZNF331 showed a consistent pattern
of maternal origin for the expressed allele. RT-PCR amplification and Sanger sequencing of SNPs in
two exons of the ZNF331 transcript (exon 1, 5'UTR and exon 7, CDS) confirmed the maternal expression.
Petre G et al (2018) reported a case with
IUGR associated with a paternally inherited duplication of a 1.06-Mb region containing ZNF331. The
methylation pattern of two methylation-specific MLPA probes within one of the CpG islands was
consistent with maternal methylation, and the authors assumed paternal expression based on previous
Three reference sequence transcripts of ZNF331 are known. The apparent discrepancies in the
parent-of-origin may be attributable to isoform specific imprinting (additional data are needed).
Biallelic expression was detected in the
5'UTR of the most 5' transcript (NM_018555).