ZNF331 (ZNF463; zinc finger protein 331) was maternally expressed in lymphoblastoid cell lines from
five children in a single CEPH family. Six unrelated individuals showed monoallelic expression of
SNPs in the 3' end of ZNF331, but biallelic expression of SNP in the 5' UTR (Pant
PV et al, 2006).
In contrast the same group later reported a pattern of differential allelic
expression that was suggestive of paternal expression (Pollard
KS et al, 2008).
By using genome-wide allele-speciﬁc protein-DNA interaction studies (ChIP-SNP), Maynard
ND et al (2009) found allele-speciﬁc binding of RNA polymerase II to ZNF331.
Three reference sequence transcripts of ZNF331 are known. The apparent discrepancies in the
parent-of-origin may be attributable to isoform specific imprinting (additional data are needed).
Biallelic expression was detected in the
5'UTR of the most 5' transcript (NM_018555).