Taxon:

Mouse

Gene:

Dhcr7 (Status questioned)

Chromosome:

07

Location:

70 cM approx

Description:

Dhcr7 (7-dehydrocholesterol reductase) was maternally expressed in E13.5 placenta, but biallelically expressed in E13.5 embryos (Schulz R et al, 2006).
However, Okae H et al, (2012) concluded that Dhcr7 by was not imprinted in mouse placenta or trophoblast stem cells. They reported relatively high expression in maternal material suggesting that the apparent imprinted maternal expression of Dhcr7 was attributable to maternal contamination of placental tissues. This result is concordant with the caution from Proudhon and Bourc'his (2010) that maternal contamination of placental tissues may cause apparent imprinted maternal expression.

Category:

Other

Record:

1101

Last Modified 2/13/2012

Links:

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